Experimental study of schisandrin B attenuates acute myocardial ischemia injury in rats by inhibiting cardiomyocyte apoptosis / 中国临床药理学与治疗学

ABSTRACT

AIM: To explore the protective effect and mechanism of schisandrin B (Sch B) on myocardial ischemia-reperfusion injury (MIRI) in rats. METHODS: Forty SD rats were randomly divided into control group, MIRI group, MIRI +30 mg/kg Sch B (MIRI + L-Sch B) group and MIRI +60 mg/kg Sch B (MIRI + H-Sch B) group, ten in each group, Sch B were intragastrically for 7 days. Ligation of the left anterior descending branch was used to establish MIRI model, control group rats only underwent sham operation. The ardiac function parameters of ejection fraction (EF), fractional shortening (FS), maximum rate of increase in left ventricular pressure (+ dp/dt