Research progress on the imbalance of coagulation and fibrinolysis system and the pathogenesis and treatment of idiopathic pulmonary interstitial fibrosis / 中国临床药理学与治疗学

ABSTRACT

Idiopathic pulmonary interstitial fibrosis (IPF) is a progressive interstitial lung disease. Its prognosis is worse than that of many cancers. Its pathogenesis is complex and unclear. The imbalance of coagulation system and fibrinolysis system was confirmed in both animal models of pulmonary fibrosis and patients with IPF. This paper expounds the possible injury mechanism of the imbalance of coagulation and fibrinolysis system in IPF, and provides a new idea for the treatment of IPF.