Chronopharmacokinetics research of helicid and its metabolites / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12): 986-994, 2021.
Artigo
em Chinês
| WPRIM
| ID: wpr-1014968
ABSTRACT
AIM:
To study chronopharmacokinetics of helicid and its metabolites.METHODS:
An HPLC-MS method for simultaneous determination of helicid and its three phase I metabolites were established and validated. At 800, 1400 and 000, the rats were given helicid 50 mg/kg by gavage, respectively. Blood samples were collected from ophthalmic venous plexus. Then plasma concentration was measured. Pharmacokinetic behaviors of the original drug and its metabolites after administration at different time points were calculated and compared.RESULTS:
This established HPLC-MS/MS method was successfully applied to simultaneous determination of helicid and its three metabolites in rat plasma after intragastric administration. Using AUC
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Pharmacology and Therapeutics
Ano de publicação:
2021
Tipo de documento:
Artigo
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