Construction and application of innovation gene-edited rats and intestinal 3D organoids models in drug metabolism and pharmacokinetics / 中国临床药理学与治疗学

ABSTRACT

Drug metabolism and pharmacokinetics (DMPK) are the science to study the process of drug absorption, distribution, metabolism and excretion. It is very important to evaluate the characteristics of DMPK for the early development of drugs and the later clinical precision medication. The innovative construction of DMPK models promotes the development and improvement of drug evaluation system. Based on our research results, this review summarized the latest progress and application of innovative DMPK models, focusing on the following two aspects (1) CRISPR/Cas9 gene editing rat models, including Cyp2e1