Quantification of ambrisentan in human plasma by LC-MS/MS and its pharmacokinetic application / 中国临床药理学与治疗学

ABSTRACT

AIM: To establish an LC-MS/MS method to determine the concentration of ambrisentan in human plasma and apply it to the study of human pharmacokinetics. METHODS: After extracting ambrisentan and internal standard from human plasma by liquid-liquid extraction, chromatographic separation was performed on a Waters Symmetry C