Effects of Wuzhi capsule on the pharmacokinetics of simvastatin and its metabolite simvastatin acid in rats / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12): 1242-1249, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-1015128
ABSTRACT
AIM:
To develop LC-MS /MS method for simultaneous determination of simvastatin and simvastatin acid concentrations in rat plasma, and investigate the pharmacokinetic effects of Wuzhi capsule (WZC) on simvastatin and simvastatin acid concentrations in rats.METHODS:
The method was based on simple liquid liquid extraction (LLE) with lovastatin as internal standard. Agilent Eclipse-C
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Pharmacology and Therapeutics
Ano de publicação:
2020
Tipo de documento:
Artigo
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