Mechanism and advance of COVID-19 on immune related pathogenesis and immunotherapy / 中国临床药理学与治疗学

ABSTRACT

The novel coronavirus pneumonia (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is pandemic globally. The progress and evolution of the disease is closely related to the immune defense function. The host immune promotes virus clearance. The dysfunction of immune compromises virus clearance, and incurs uncontrolled inflammatory response which causes immune pathological injury and makes the disease worse. Therefore, the application of immunotherapy for immune disorders caused by SARS-CoV-2 infection is expected to be an effective strategy for the treatment of COVID-19.