Research progress on neural mechanism of pancreatic cancer pain / 解剖学报

ABSTRACT

Pancreatic cancer pain is a kind of visceral pain caused by cancer. Patients often have the characteristics of left upper abdominal pain and band radiation on the back, which seriously affects the prognosis and quality of life of the patients. Pancreas is a retroperitoneal organ and distributed with sympathetic nerve and parasympathetic nerve. The mechanism of pancreatic cancer pain is complex, such as the invasion of peripheral nerve by tumor cells, the activation of receptor by mastocyte departiculate action, the proliferation of new capillaries, the involvement of glial cells, and the related molecular mechanisms. It is necessary to understand the neuroanatomical characteristics of pancreas and explore the mechanism of pancreatic cancer pain in order to relieve the pain and improve the prognosis and quality of life of patients with pancreatic cancer. In this paper, the neuropathic pain mechanism of pancreatic cancer is reviewed in order to provide a new target and strategy for clinical treatment.