The Molecular Mechanism of SIRT1-Catalysed Deacetylation on Non-Histone Proteins and Its Impact on Cell Apoptosis / 中国生物化学与分子生物学报

ABSTRACT

Sirtuins belongs to the class III family of histone deacetylases (HDAC), which is a mammalian homolog of the yeast silencing information regulator Sir2. Silent information regulator factor 2-related enzyme 1 (SIRT1) is the most well studied family member of Sirtuins. Distributed mainly in the nucleus and cytoplasm, SIRT1 is involved in various intracellular biological processes, including DNA damage repair, gene transcription, energy metabolism, stress and apoptosis through its NAD