JNK-mediated Neuroprotective Mechanism after Ischemic Stroke in Rats / 中国生物化学与分子生物学报
Chinese Journal of Biochemistry and Molecular Biology
;
(12): 967-973, 2021.
Artigo
em Chinês
| WPRIM
| ID: wpr-1015914
ABSTRACT
In order to explore the protective mechanism of stress-activated protein kinase JNK on neurons after ischemic stroke,the model of middle cerebral artery occlusion (MCAO) in male SD rats was established by suture methods. Anisomycin (AN), a JNK agonist, was added at the characteristic time point of autophagy, and then Western blotting and immunofluorescence were used to detect the protein expression of autophagy flow pathways in ischemic penumbra, and the effects of JNK on the stability of Bcl-2-Beclin1 complex and autophagy flow pathway were analyzed. The results showed that compared with the MCAO+Veh group, the expression levels of LC3 (
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Biochemistry and Molecular Biology
Ano de publicação:
2021
Tipo de documento:
Artigo
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