Important Molecules in New Targeted Drug Research: Variable Lymphocyte Receptors / 中国生物化学与分子生物学报

ABSTRACT

Since the first discovery of lamprey variable lymphocyte receptors (VLRs) in 2004, the research and modification of VLRs have been very hot.VLRs have simple molecular structure, stable physical and chemical properties.VLRs can recognize a variety of antigens and have high affinity and strong specificity for proteins and polysaccharides, et al.In recent years, the recombinant molecules constructed by VLRs have been widely used in basic and application research in various fields.This paper reviews the latest application research of VLRs downstream in recent years.In tumor, VLRs can specifically and accurately identify carbohydrates and polysaccharides with only one functional group.It can be used as a sensitive anti-polysaccharide reagent to identify unique carbohydrate complexes on tumor cells and provide a new strategy for tumor targeted therapy.VLRs can also be combined with other classical therapies, such as modifying chimeric antigen receptors to express a synthetic receptor that redirects the targeted killing of T cells to the selected target.After recombination and modification, VLRs can also improve separation and purification of reagents.Research also indicates that VLRs play a role in aquatic diseases.These newly developed VLRs may be used as new reagents for identification, diagnosis and treatment.This paper describes the mechanism of VLRs diversity, and the relationship between VLRs with sugar biology and biomedical research, including the role of VLRs in improving separation and purification reagents, and the application of VLRs in the study of aquatic diseases.This review may provide reference for the application of VLR in disease drug research and development.