Exploring Pathogenic Mechanisms of Non-alcoholic Fatty Liver Disease Based on Mitochondrial Dysfunction and Endoplasmic Reticulum Stress / 胃肠病学
Chinese Journal of Gastroenterology
;
(12): 751-754, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-1016061
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease caused by abnormal accumulation of fat in the hepatocytes. Its prevalence is rising globally and has become the most common cause of chronic liver disease worldwide. The pathogenesis of NAFLD is multifaceted, involving insulin resistance, genetic and epigenetic factors, chronic systemic inflammation, mitochondrial dysfunction, endoplasmic reticulum stress, diet, gut microbiota, and other significant contributors. This article primarily delves into the mechanisms of mitochondrial dysfunction and endoplasmic reticulum stress in the development of NAFLD, aiming to provide new insights and therapeutic strategies for NAFLD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Gastroenterology
Ano de publicação:
2022
Tipo de documento:
Artigo
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