Progress in Study on Relationship Between Microbiome Dysbiosis and Pathogenesis of Esophageal Diseases / 胃肠病学

ABSTRACT

With the development of the genomic sequencing of human commensal microbiome and bioinformatics, the role of esophageal microbiome in the pathogenesis of gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), esophageal adenocarcinoma (EAC), and esophageal squamous cell carcinoma (ESCC) has been attracted much attention. Esophageal microbiome are relatively stable, but changes such as age, diet, use of drugs, oral hygiene, smoking, etc. can break the balance between esophageal microbiome and host immunity, and lead to persistent dysbacteriosis, increasing the risk of local inflammation and systemic inflammation and ultimately lead to the progression of many diseases. This article reviewed the progress in study on relationship between microbiome dysbiosis and pathogenesis of esophageal diseases.