Research Progress on Relationship Between Potassium Channels and Visceral Hypersensitivity / 胃肠病学

ABSTRACT

Visceral hypersensitivity is one of the pathogenesis of functional gastrointestinal disorders (FGIDs) including irritable bowel syndrome and functional dyspepsia. In recent years, more and more studies have suggested that the occurrence of gastrointestinal hypersensitivity is related to the changes of neuronal plasticity in the intestinal nervous system or afferent pathway, and potassium channels play a crucial role in controlling neuronal excitability. Lots of studies have shown that decreased expressions or activities of voltage-gated potassium channels, calcium-activated potassium channels, and two-pore domain potassium channels in nociceptors can increase the excitability of neurons, increase visceral pain, and participate in the occurrence of FGIDs. This article reviewed the research progress on relationship between potassium channels and visceral hypersensitivity.