Effect of Fluoxetine on Metabolic Diversity of Intestinal Microbiota in Rats With Depression / 胃肠病学
Chinese Journal of Gastroenterology
; (12): 342-347, 2021.
Article
em Zh
| WPRIM
| ID: wpr-1016213
Biblioteca responsável:
WPRO
ABSTRACT
Background: Studies have shown that intestinal microbiota is closely related to the occurrence and development of depression, however, the regulatory mechanism of the classic antidepressant fluoxetine on intestinal microbiota is still unclear. Aims: To investigate the mechanism of fluoxetine in regulating intestinal microbiota structure and metabolic diversity in rats with depression. Methods: Thirty SD rats were randomly divided into blank group, model group and fluoxetine group. Depression rat model was established by chronic unpredictable mild stress (CUMS) combined with solitary care. Fluoxetine hydrochloride dispersible tablets 3.17 mg•kg
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Gastroenterology
Ano de publicação:
2021
Tipo de documento:
Article