Progress of Research on Forkhead Box Q1 Gene in Digestive Tract Tumors / 胃肠病学

ABSTRACT

Transcription factor forkhead box Q1 (FOXQ1) is a member of forkhead box (FOX) superfamily, which exists widely in a variety of tissues and organs of human body. FOXQ1 protein affects the genesis, progression, invasion and metastasis of tumor by promoting epithelial-mesenchymal transition (EMT) and activating multiple cell signal transduction pathways. In recent years, studies have found that FOXQ1 is abnormally expressed in a variety of digestive tract tumors. In-depth study on the expression and mechanism of FOXQ1 in digestive tract tumor is of great significance for early diagnosis and specific molecular therapy of digestive tract tumors. This article reviewed the latest literatures related to FOXQ1 and digestive tract tumors, and expounding its mechanism in the progression of different digestive tract tumors, in order to provide theoretical basis and reference for the research and development of new chemotherapy drugs.