Advances in Studies on Short-chain Fatty Acids in Inflammatory Bowel Disease / 胃肠病学

ABSTRACT

Inflammatory bowel disease (IBD) is a chronic inflammatory disease driven by genetic and environmental factors. Short-chain fatty acids (SCFAs), which are produced by fermentation of dietary fiber by intestinal microbiota, have anti-inflammatory effect and are involved in the maintenance of intestinal homeostasis. Intestinal inflammation and low fiber diet can reduce the number of SCFAs-producing bacteria and thereby affecting intestinal immune and metabolic regulation. This article reviewed the advances in studies on SCFAs in IBD.