Research Progress on Related Genes of Gastroesophageal Reflux Disease / 胃肠病学

ABSTRACT

Gastroesophageal reflux disease (GERD) is a common disease with complex pathogenesis and poor efficacy of traditional treatments. With the development of molecular biotechnology, it is demonstrated that gene polymorphisms such as IL-1B, IL-1RN, PAR-2, and GSTP1 can increase disease susceptibility, while COX-2, CDX-2, MMPs, EGF and other genes can promote the development of GERD into Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). The study of genetics will contribute to the prevention and treatment of the disease. This article reviewed the role of related genes in the occurrence, development and carcinogenesis of GERD.