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Value of MRI biliary score and liver/muscle ratio in evaluating the pathological grade of liver fibrosis / 临床肝胆病杂志
Journal of Clinical Hepatology ; (12): 720-725, 2024.
Artigo em Chinês | WPRIM | ID: wpr-1016515
ABSTRACT
ObjectiveTo investigate the value of biliary score and hepatic signal intensity-to-muscle signal intensity ratio (HMR) obtained by multiphase contrast-enhanced MRI scan using Gd-EOB-DTPA in evaluating the pathological grade of liver fibrosis. MethodsA retrospective analysis was performed for the MRI and clinical data of 51 patients with chronic hepatitis B liver fibrosis in Wuming Hospital Affiliated to Guangxi Medical University from January 2020 to May 2023. The 51 patients with liver fibrosis were divided into low-grade group (S1-S2) and high-grade group (S3-S4). GE Architact 3.0T MR scanner was used to perform MRI scans, including routine plain scan and contrast-enhanced scan at arterial phase, portal venous phase, delayed phase, hepatobiliary phase, and excretory phase, and biliary score and HMR were measured for the patients with different grades of liver fibrosis. The t-test was used for comparison of continuous data between groups, and the chi-square test or the Fisher’s exact test was used for comparison of categorical data between groups. The receiver operating characteristic (ROC) curve was plotted to evaluate the value of MRI indicators in determining the pathological grade of liver fibrosis. ResultsAmong the 51 patients with liver fibrosis, there were 30 patients in the low-grade group and 21 in the high-grade group. Compared with the high-grade group, the low-grade group had significantly higher biliary score (3.67±0.55 vs 2.57±0.75, t=6.05, P<0.001) and HMR at portal venous phase (2.38±0.76 vs 1.97±0.18, t=2.41, P=0.020), delayed phase (2.48±0.70 vs 1.99±0.27, t=3.09, P=0.003), and hepatobiliary phase (4.10±0.63 vs 3.16±0.47, t=5.81, P<0.001). The above indicators had an area under the ROC curveAUC) of 0.86, 0.79, 0.82, and 0.88, respectively, in distinguishing low- and high-grade liver fibrosis, with a positive rate of 70%, 63.3%, 83.3%, and 96.7%, respectively, and a negative rate of 90%, 95.2%, 74.1%, and 100%, respectively, in the diagnosis of high-grade liver fibrosis. Biliary score combined HMR had an AUC of 0.95, with a positive rate of 85.7% and a negative rate of 96.7%. ConclusionBiliary score and HMR at hepatobiliary phase obtained by multiphase contrast-enhanced MRI scan using Gd-EOB-DTPA has a relatively high diagnostic efficacy in distinguishing between low- and high-grade liver fibrosis and a certain guiding value for the diagnosis and treatment of liver fibrosis in clinical practice.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Clinical Hepatology Ano de publicação: 2024 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Clinical Hepatology Ano de publicação: 2024 Tipo de documento: Artigo