Expression of serum sCD14-ST in children with bacterial pneumonia and its relationship with pathogen infection types and disease outcome / 国际检验医学杂志

ABSTRACT

Objective To investigate the expression of serum soluble leukocyte differentiation antigen 14 subtype(sCD14-ST)in children with bacterial pneumonia and its relationship with the types of pathogen in-fection and disease outcome.Methods A total of 98 children with bacterial pneumonia admitted to the hospi-tal from January 2022 to March 2023 were selected as the bacterial pneumonia group.According to the types of pathogen infection infection,the children were divided into gram-negative bacteria group(70 cases)and gram-positive bacteria group(28 cases).Another according to the patient's short-term curative effect,the chil-dren will be divided into good curative effect group(68 cases)and poor curative effect group(30 cases).A to-tal of 30 healthy children who underwent physical examinations in the same hospital during the same period were selected as the control group.Serum levels of sCD14-ST,C-reactive protein(CRP)and procalcitonin(PCT)were measured and compared in each group.Pearson correlation was used to analyze the correlation be-tween serum sCD14-ST level and CRP and PCT in children with bacterial pneumonia.Receiver operating char-acteristic(ROC)curve was used to analyze the value of serum sCD14-ST,CRP and PCT levels on the disease outcome of children with bacterial pneumonia.Results The levels of CRP,PCT and sCD14-ST in bacterial pneumonia group were higher than those in control group(P<0.05).The serum levels of CRP,PCT and sCD14-ST in the Gram-negative bacteria group were higher than those in the Gram-positive bacteria group(P<0.05).The levels of serum CRP,PCT and sCD14-ST in the good curative effect group were lower than those in the poor curative effect group(P<0.05).Pearson correlation analysis showed that the serum sCD14-ST level was positively correlated with CRP and PCT in children with bacterial pneumonia(r=0.498,0.526,P<0.05).ROC analysis showed that the area under the curve of serum sCD14-ST,CRP,and PCT in predic-ting the outcome of bacterial pneumonia in children was 0.867(95%CI 0.785-0.950),0.759(95%CI 0.653-0.865),and 0.847(95%CI 0.759-0.935),respectively.Conclusion The serum sCD14-ST level is abnormally increased in children with bacterial pneumonia,and it is related to the type of pathogen infection and clinical outcome.The serum sCD14-ST level has a certain evaluation value for the outcome of pathogen in-fection pneumonia in children.