Research progress in preparation and applications of myocardial patches in myocardial infarction treatment / 国际生物医学工程杂志

ABSTRACT

Myocardial infarction caused by myocardial ischemia can lead to the loss of cardiomyocytes, resulting in the replacement of the myocardial infarction area with scar tissue and ultimately leading to heart failure. However, the treatment options are currently very limited. Currently, myocardial patch therapy is a promising strategy for treating severe myocardial infarction. This approach is based on engineering principles and involves combining seed cells or biological active substances with suitable scaffold materials to construct biomaterials that can be used for transplantation, repair, or replacement of autologous myocardium. The biomaterial scaffolds for engineered myocardial patches are usually prepared by means of acellular matrix, electrospinning technology, 3D biological printing, hydrogel, cell patch and other methods. In this paper, the preparation methods of myocardial patches and their application progress in myocardial infarction treatment are reviewed.