Summary of molecular characteristics of iodine refractory differentiated thyroid carcinoma / 国际外科学杂志

ABSTRACT

The clinical manifestation of iodine-refractory differentiated thyroid cancer (RAIR-DTC)is resistance to iodine therapy, which can not achieve the therapeutic effect and affect the prognosis of patients. Iodine-refractory thyroid cancer is mainly due to the decrease or disappearance of the expression of sodium-iodine isotransporters, the expression of some thyroid specific genes and the change of signaling pathway caused by some gene mutations. In this paper, the molecular characteristics of RAIR-DTC will be introduced and expounded, hoping to enhance understanding of RAIR-DTC, and provide help for targeted drug therapy of it.