TGF-β/Smad signal pathway and acute leukemia / 国际肿瘤学杂志

ABSTRACT

Transforming growth factor-β (TGF-β) /Smad signaling pathway is an important signaling pathway in human cells, which can regulate life activities such as cell growth, proliferation and apoptosis, and its signal transduction consists of ligand and receptor binding, intracytoplasmic signaling pathway, as well as interactions within the cell nucleus. This signaling pathway is closely related to the pathogenesis, drug resistance, recurrence and prognosis of acute leukemia. Exploring the potential of direct inhibitors, related therapeutic targets and natural extracts of this signaling pathway for the treatment of leukemia can provide new ideas for the study of biomarkers and targeted gene therapy for leukemia.