Establishment of Reference Ranges for Plasma Soluble Fibrin Monomer Complex Level at Different Gestational Periods of Women in Yibin Area of Sichuan / 现代检验医学杂志

ABSTRACT

Objective To explore the changes in plasma soluble fibrin monomer complex(SFMC)levels at different gestation periods of healthy women in Yibin area of Sichuan and establish reference ranges for SFMC at different gestational stages.Methods A total of 377 healthy pregnant women and 120 health examinees who received antenatal examination in Yibin Maternal and Child Health Care Hospital from May 2021 to January 2022 were enrolled in this study and grouped into the early pregnant group,the second trimester group,the late pregnant group and control group.The plasma SFMC and D-dimer(D-D)of all groups were detected using the latex immunoturbidimetry and reference ranges of SFMC were established for each group.Meanwhile,the correlation between SFMC and D-D was analyzed at the same time.Results The reference ranges of SFMC in the control group,the early pregnant group,the second trimester group and the late pregnant group were＜7.3μg/ml,＜18.4μg/ml,＜20.4μg/ml and＜58.5μg/ml,respectively.The difference between groups was statistically significant(F=55.989,P＜0.001),and the plasma SFMC levels showed an upward trend as pregnancy progressed.The SFMC level in plasma was positively correlated with the D-D level(r2=0.468 8).Conclusion The plasma SFMC levels in pregnant women significantly increased with the progression of pregnancy,and the reference range of the normal population cannot meet the risk assessment of venous thrombosis in pregnant women.This study preliminary established reference ranges for plasma SFMC in women at different gestation periods,which has important clinical significance for monitoring and preventing venous thromboembolism in pregnant population.