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Clathrin and Lipid Raft-dependent Internalization of Porphyromonas gingivalis in Endothelial Cells
International Journal of Oral Biology ; : 131-136, 2014.
Artigo em Inglês | WPRIM | ID: wpr-102299
ABSTRACT
Porphyromonas gingivalis is one of the most important periodontal pathogens and has been to known to invade various types of cells, including endothelial cells. The present study investigated the mechanisms involved in the internalization of P. gingivalis in human umbilical vein endothelial cells (HUVEC). P. gingivalis internalization was reduced by clathrin and lipid raft inhibitors, as well as a siRNA knockdown of caveolin-1, a principal molecule of lipid raft-related caveolae. The internalization was also reduced by perturbation of actin rearrangement, while microtubule polymerization was not required. Furthermore, we found that Src kinases are critical for the internalization of P. gingivalis into HUVEC, while neither Rho family GTPases nor phosphatidylinositol 3-kinase are required. Taken together, this study indicated that P. gingivalis internalization into endothelial cells involves clathrin and lipid rafts and requires actin rearrangement associated with Src kinase activation.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fosfotransferases / Polímeros / Actinas / Clatrina / Porphyromonas gingivalis / Quinases da Família src / Cavéolas / RNA Interferente Pequeno / Células Endoteliais / Caveolina 1 Limite: Humanos Idioma: Inglês Revista: International Journal of Oral Biology Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fosfotransferases / Polímeros / Actinas / Clatrina / Porphyromonas gingivalis / Quinases da Família src / Cavéolas / RNA Interferente Pequeno / Células Endoteliais / Caveolina 1 Limite: Humanos Idioma: Inglês Revista: International Journal of Oral Biology Ano de publicação: 2014 Tipo de documento: Artigo