Synthesis and biological effects of N-hydroxy-methyl-5-bromoisatine and derivatives
Pharmaceutical Journal
;
: 4-5, 1999.
Artigo
em Vietnamita
| WPRIM
| ID: wpr-1024
ABSTRACT
By bromation of isatin 5-bromoisatin (I) was obtained. On boiling (I) with 4% formaldehyde solution for short period of time, a compound was isolated which has been characterized as N-hydroxymethyl-5-bromoisatin (II). By condensation of I with various H2N-B compounds, 6 derivatives (III-VIII) were formed. The structures of the obtained products were characterized by IR spectroscopy (II was characterized by MS, 1H.NMR). The synthesized compounds were tested for biological activities such as antibacterial and antifungal. Among these, two compounds (I, II) showed an antibacterial activity on 8 strains of bacteria. Compound VI showed an antibacterial activity on 3 strains of bacteria. Compound VI showed an antibacterial activity on 3 strains of bacteria.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Bufotenina
/
Antibacterianos
Idioma:
Vietnamita
Revista:
Pharmaceutical Journal
Ano de publicação:
1999
Tipo de documento:
Artigo
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