Comparison of effects of low-dose esketamine and sufentanil on perioperative analgesia for hip arthroplasty / 局解手术学杂志

ABSTRACT

Objective To compare the application effects of low-dose esketamine and sufentanil on perioperative analgesia in patients undergoing hip arthroplasty(HA).Methods A total of 124 patients who underwent HP in our hospital were divided into the control group and the observation group according to random number table,with 62 cases in each group.Patients in the control group were given sufentanil for analgesia,and patients in the observation group were given low-dose esketamine for analgesia.The hemodynamics changes of the heart rate(HR),respiratory rate(RR),mean arterial pressure(MAP)and oxygen saturation(SpO2)of patients before anesthesia(T1),at the time of incising skin(T2),after 30 minutes of anesthesia(T3)and at the end of surgery(T4)in both groups were observed.The visual analogue scale(VAS)scores of patients in resting state and active state before surgery(T5),6 hours after surgery(T6),12 hours after surgery(T7)and 24 hours after surgery(T8)were recorded.The number of postoperative analgesic pump compression,need of supplemental analgesic drugs and occurrence of adverse reactions during surgery and 24 hours after surgery of patients in the two groups were recorded.Results There was no statistically significant difference in HR,MAP or RR at T1 of patients between the two groups(P>0.05).The levels of HR,MAP and RR at T2,T3 and T4 of patients in the observation group were higher than those in the control group(P<0.05).There was no statistically significant difference in SpO2 at each time points between the two groups(P>0.05).There was no statistically significant difference in the VAS scores at T5 of patients in resting state or active state(P>0.05).The VAS scores at T6,T7 and T8 of patients in resting state and active state in the observation group were lower than those in the control group(P<0.05).The number of postoperative analgesic pump compression and the proportion of patients with the need of supplemental analgesic drugs in the observation group were less/lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of intraoperative and postoperative adverse reactions of patients between the two groups(P>0.05).Conclusion Compared with sufentanil,low-dose esketamine has better analgesic effect for IA patients,with milder perioperative pain degree,more stable intraoperative hemodynamics,and better safety.