Analysis of survival factors and prediction of metastasis in patients with gallbladder carcinoma / 中国现代普通外科进展

ABSTRACT

Objective:To analyze the factors affecting the survival cycle of gallbladder cancer patients and to predict whether patients had lymph node metastasis or distant metastasis in early stage by tumor markers.Methods:We reviewed the clinical data of 73 gallbladder cancer patients with definite diagnosis admitted to our hospital from January 2017 to December 2021 in surgery and followed up their survival cycles,analyzed the influence of each clinical data on patients'survival,and predicted tumor metastasis by tumor markers.Results:The univariate and multivariate analysis showed that distant metastasis,the number of positive tumor markers and TNM stage were inde-pendent factors affecting the survival of patients with gallbladder carcinoma.According to the re-ceiveroperatingcharacteristic,ROC curve drawn by tumor markers,it can be inferred that there may be lymph node metastasis when the concentrations of CEA and CA125 are higher than 7.07 ng/mL and 38.875 U/mL respectively.Conclusion:The survival cycle of patients with gallbladder cancer is affected by many factors.Screening of patients with high risk factors should be strengthened and disease progression should be judged according to the expression level of tumor markers in order to carry out effective clinical intervention.