Research progress on the function of macrophages in preterm delivery / 中国医师杂志

ABSTRACT

Premature birth is one of the main challenges faced by modern obstetrics, and there is still a lack of effective treatment methods. The successful pregnancy process depends on the immune balance at the maternal fetal interface, and due to the unique antigen presenting molecules and immune recognition receptors on the surface of macrophages, they play a crucial role in maternal fetal immune tolerance. The dysfunction of uterine macrophages can lead to various adverse pregnancy outcomes. This review summarizes the latest research progress on the origin of macrophages, their specialization in the uterine microenvironment, their physiological functions at different stages of pregnancy, and their role in preterm delivery.