Chronic Obstructive Pulmonary Disease Increases the Risk of New-onset Atrial Fibrillation and Mortality of Patients with Atrial Fibrillation
International Journal of Arrhythmia
;
: 176-184, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-102705
ABSTRACT
BACKGROUND:
Although a few previous studies have analyzed the role of reduced lung function in predicting atrial fibrillation (AF), the relationship between the incidence of AF and comorbid chronic obstructive pulmonary disease (COPD) is unclear. We hypothesized that COPD is associated with the occurrence of new-onset AF and clinical outcomes in AF patients.METHODS:
We analyzed the development of new-onset AF in 501,668 patients without AF and clinical outcomes in 4,541 patients with AF using Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC).RESULTS:
Comorbid COPD was found in 4.8% (11,442 of 501,668) of non-AF patients and 18.6% (820 of 4,541) of AF patients. The incidence of AF in COPD patients was significantly higher compared to non-COPD patients (2.6% vs. 0.6%, p < 0.001) over the follow-up period (45.5±14.9 months). In a multivariate Cox regression analysis, COPD predicted higher risk of AF independently from other risk factors (HR 1.41, 95% CI 1.25-1.60, p < 0.001). The allcause mortality of AF patients with COPD was significantly higher in patients who used b-blockers (20.6% vs 13.1% during follow-up, p < 0.008). Multivariate Cox regression analysis showed that COPD is still an independent risk factor for all-cause mortality (HR 1.25, 95% CI 1.03–1.51, p=0.022), and stroke (HR 1.19, 95% CI 1.00–1.41, p=0.039).CONCLUSION:
The presence of COPD is an independent risk factor for new-onset AF. COPD is independently associated with all-cause mortality and stroke in AF patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fibrilação Atrial
/
Incidência
/
Fatores de Risco
/
Estudos de Coortes
/
Seguimentos
/
Mortalidade
/
Acidente Vascular Cerebral
/
Doença Pulmonar Obstrutiva Crônica
/
Pulmão
/
Programas Nacionais de Saúde
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
International Journal of Arrhythmia
Ano de publicação:
2017
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS