Histologic Study of Injected Dermal Fillers (Artecoll(R), Restylane(R), Sheba(R)) in Mouse

ABSTRACT

Many attempts have been made to fill the space the dermis with biological or artificial implants. The ideal injectable material should be biocompatible, nonantigenic, nonpyrogenic, noninflammatory, nontoxic, easy to use, stable for injection, non-migratory, long-lasting, and not too expensive. This study was designed in order to select the ideal injectable filler material among PMMA microspheres suspended in collagen solution(Artecoll(R)), micronized allderm(Sheba(R)), and hyaluronic acid (Restylane(R)). We divided into 3 groups according to the injected material (Group I; Artecoll(R) , Group II; Restylane(R) , Group III; Sheba(R)). 0.2 ml of Artecoll(R) was injected into back skin of group I mice in subdermal plane. 0.2 ml of Restylane(R) & Sheba(R)were injected intradermally group II & III in each. The biopsy specimens were taken from each group at 3 day, 1 week, 4 weeks, 12 weeks, 24 weeks after injection and examined grossly as well as histologically. Three matrials showed mild inflammatory response until 4 weeks and disappeared until 12 weeks. Foreign body giant cell has not been shown in any section. In Artecoll(R) and Sheba(R) group, the volume of injected materials was reduced significantly at 24 weeks, but that of Restylane(R) group maintained at 24 weeks. In conclusion, Restylane(R) might be more ideal as an injectable filler than Artecoll(R) and Sheba(R) in this study.