Factors influencing the severity of acute viral hepatitis A / 대한간학회지
The Korean Journal of Hepatology
;
: 295-300, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-103209
ABSTRACT
BACKGROUND/AIMS:
Most patients with acute viral hepatitis A have a favorable course, but a few of them suffer from severe forms of hepatitis such as fulminant hepatitis. This study was carried out to identify the factors influencing the severity of acute viral hepatitis A.METHODS:
We retrospectively reviewed the medical records of 713 patients with acute hepatitis A, who were divided into two groups severe hepatitis A (N=87) and non-severe hepatitis A (N=626). Severe hepatitis was defined as fulminant hepatitis or prolongation of prothrombin time (INR> or =1.5). Clinical variables were compared between the two groups.RESULTS:
The incidence of fulminant hepatitis was 1.4 % (10/713) in patients with acute hepatitis A. Thirty-three (4.6 %) cases exhibited HBsAg positivity. In multivariate analyses, significant alcohol intake and the presence of HBsAg were significant predictive factors of fulminant hepatitis A, and significant alcohol intake and age were significant predictive factors of severe hepatitis A. HBeAg and HBV-DNA status did not affect the clinical course of hepatitis A in chronic hepatitis B carriers.CONCLUSIONS:
While most patients with acute hepatitis A have an uncomplicated clinical course, our data suggest that a more-severe clinical course is correlated with being older, significant alcohol intake, and chronic hepatitis-B-virus infection. (
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tempo de Protrombina
/
Índice de Gravidade de Doença
/
Consumo de Bebidas Alcoólicas
/
Doença Aguda
/
Valor Preditivo dos Testes
/
Estudos Retrospectivos
/
Fatores Etários
/
Falência Hepática Aguda
/
Hepatite B Crônica
/
Hepatite A
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2010
Tipo de documento:
Artigo
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