Cytomegalovirus Infection under a Hybrid Strategy in Pediatric Liver Transplantation: A Single-Center Experience / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
;
: 178-185, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-103263
ABSTRACT
PURPOSE:
To evaluate the outcomes of a hybrid prophylactic strategy to prevent cytomegalovirus (CMV) disease in pediatric liver transplantation (LT) patients.METHODS:
CMV DNAemia was regularly monitored by quantitative nucleic acid amplification test (QNAT) and was quantified in all children. CMV infection and disease were defined according to the International Consensus Guidelines. The hybrid strategy against CMV infection consisted of universal 3-week prophylaxis and preemptive treatment of intravenous ganciclovir regardless of the recipient's serostatus.RESULTS:
A total of 143 children who underwent living donor LT were managed using the hybrid strategy. The overall incidence of CMV infection by QNAT was 48.3% (n=69/143). The highest CMV DNAemia positivity was observed in 49.2% (n=60/122) of children in the D+/R+ group, followed by 46.7% (n=7/15) in the D+/R− group. CMV disease was noted in 26.1% (n=18/69) patients. Forty-three (62.3%) children had undergone preemptive therapy consisting of intravenous ganciclovir. No symptomatic patients developed tissue-invasive disease, resulting in no CMV-associated mortality.CONCLUSION:
The incidence of CMV infection was high in pediatric LT patients despite the hybrid strategy. However, tissue-invasive disease in pediatric LT did not occur.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ganciclovir
/
Incidência
/
Mortalidade
/
Transplante de Fígado
/
Infecções por Citomegalovirus
/
Doadores Vivos
/
Técnicas de Amplificação de Ácido Nucleico
/
Citomegalovirus
/
Consenso
/
Fígado
Tipo de estudo:
Guia de Prática Clínica
/
Estudo de incidência
/
Estudo prognóstico
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Pediatric Gastroenterology, Hepatology & Nutrition
Ano de publicação:
2017
Tipo de documento:
Artigo
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