Clinical observation of Shuxuetong injection for intracerebral hemorrhage at acute phase / 中华神经医学杂志

ABSTRACT

Objective To observe the curative effect of Shuxuetong injection on intracerebral hemorrhage at acute phase. Methods Sixty patients with intracerebral hemorrhage at acute phase were randomly divided into treatment group and control group (n=30). The treatment group intravenously received 6 mL Shuxuetong daily for 15 consecutive d and control group was treated with routine treatment. CT was performed to evaluate the volumes of hematomas, the changes of low-density areas surrounding the hematomas on the 1st, 7th and 15th d of treatment, respectively. The neurologic impairment evaluation scores were recorded with National Institutes of Health Stroke Scale (NIHSS). Monitor on plasma fibrinogen level was performed in both groups. Results No significant differences on the volumes ofhematomas, low-density areas surrounding the hematomas, neurologic impairment evaluation scores, and plasma fibrinogen level were noted between the 2 groups on the admission day (P＞0.05). On the 7th and 15th d of treatment, volumes of hematomas, low-density areas surrounding the hematomas and neurologic impairment evaluation scores in the treatment group reduced significantly as compared with those in the control group (P＜0.05), however, plasma fibrinogen level was not statistically different between the 2 groups (P＞0.05). Conclusion Shuxuetong injection is superior to routine treatment in reduction of volumes of hematomas, low-density areas surrounding the hematomas, neurologic impairment evaluation scores, but not in reduction of plasma fibrinogen level.