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The Metabolism of Benzidine-based Dye Direct Black 38 in the Isolated Perfused Rat Liver / 대한산업의학회지
Korean Journal of Occupational and Environmental Medicine ; : 59-65, 1996.
Artigo em Coreano | WPRIM | ID: wpr-103379
ABSTRACT
Direct Black 38, a kind of benzidine-based azo dye, is widely used as a dye for fabric, leather, cotton, cellulosic material, paper, wool, silk, and so on. Benzidine-based azo dyes are proven as a mutagen and linked to bladder cancer. In 1978, Natonal Institute for Occupational Safety and Health recommended that three widely used benzidine-based dyes (Direct Black 38, Direct Blue 6, and Direct Brown 95) should be treated as carcinogens. In this experiment, metabolism of the benzidine-based dye. Direct Black 38 was examined by using an isolated liver perfusion system. To measure the metbolites of Direct Black 38,/ 8.0 micrometer, 30.5 micrometer and 63,3 micrometer of Direct Black 38 was added into the recirculating perfusate of the isolated perfused rat liver. Samples were collected at 0, 10, 20, 30, 60, 90. 120 minute. They were treated with sep-pak and methanol, and the metabohtes were detected and quantified with high performance liquid chromatography (HPLC). Residual non-reactive dye in the perfusate and liver was reduced to benzidine and then analyzed by HPLC. Detected metabolites of ?Direct
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Perfusão / Lã / Neoplasias da Bexiga Urinária / Carcinógenos / Cromatografia Líquida de Alta Pressão / Cromatografia Líquida / Saúde Ocupacional / Seda / Metanol / Corantes Limite: Animais Idioma: Coreano Revista: Korean Journal of Occupational and Environmental Medicine Ano de publicação: 1996 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Perfusão / Lã / Neoplasias da Bexiga Urinária / Carcinógenos / Cromatografia Líquida de Alta Pressão / Cromatografia Líquida / Saúde Ocupacional / Seda / Metanol / Corantes Limite: Animais Idioma: Coreano Revista: Korean Journal of Occupational and Environmental Medicine Ano de publicação: 1996 Tipo de documento: Artigo