Three-dimensional reconstruction of subthalamic nucleus for optimal electrode angle of deep brain stimulation in Parkinson's disease patients / 中华神经医学杂志

ABSTRACT

Objective To measure the parameters of the specific electrode trajectory angles under the condition that the trajectory length in the nuclei could be as long as possible by using 3D reconstruction of subthalamic nucleus (STN).Methods A 3D atlas of deep brain nuclei was built on the 3D reconstruction station,and the parameters of STN were measured.MR imaging of 30 Parkinson's disease (PD) patients was matched to the 3D atlas to acquire the average nucleus information.Results The STN spatial location parameters showed no significant statistical difference with imaging of these 30 patients (95％ confidence interval of difference value＜l),indicating that this 3D atlas enjoyed good representative value.After simulation,the optimal trajectory angles were achieved:the combination angles ofring/slide:55°-57°/17°-19°,which extended the trajectory within the nucleus to about (5.7±0.3)mm.Conclusion The 3D atlas shows high representative of locating deep brain nucleus and could be registrated well to particular patient's images.After simulation on the atlas,the optimal trajectory angles parameters can be obtained,which shows the specific operation of achieving longer length of electrode in nucleus.