Openly study of high-risk factors of epilepsy relapse after single antiepileptic drug withdrawal / 中华神经医学杂志

ABSTRACT

Objective To analyze the high-risk factors of epilepsy relapse through observing the replapse one year after drug withdraw in epileptic patients with single antiepileptic drug (AED) treatment who had no clinic attack for 3 years.Methods One hundred and two epileptic patients,had no clinic attack for 3 years,and no epileptic discharges or discharges less than 5 times in their 24-hours video electroencephalogram (VEEG) before single AED withdrawal,were chosen in our study from January 2006 to June 2014; follow up was performed on these patients until epilepsy relapse or at least one year for those without relapse.Their age,gender,epileptic discharges in VEEG before withdrawal,epileptic forms,types,frequencies,degrees and classifies,etiology,encephalic epileptic focus,initiate treatment time and AED kinds were analyzed.Results Finally,77 patients were selected and 27 (35.1％) relapsed within one year of AEDs withdrawal.Relapse was connected with multiple epileptic forms,initiate treatment times,frequencies,and encephalic epileptic focus (P＜0.05); there were no obvious precipitating factors for 40.7％ patients; the others were connected with unhealthy living habits,infections,rage or passion.Conclusion High-risk factors for relapse exist after single ADE withdrawal; determination of these factors can help to prevent epilepsy relapse.