Recent advance in role of Drebrin in neural development and cognitive disorders / 中华神经医学杂志

ABSTRACT

Developmentally regulated brain protein (Drebrin),which is a kind ofactin binding protein,mainly distributes in the neuronal dendritic spines.It plays an important role in the processes of formation of dendritic spines,adjustment of synaptic morphology,and memory keep.The quantity and distribution of Drebrin changed in some of the central nervous system diseases such as Alzheimer's disease in brain tissues.Researchers have made much effort to find the correlation of them,but the exact mechanism is unclear.A more in-depth study on mechanism of Drebrin in the central nervous system disease and correlation of Drebrin with associated molecule has great significance to exploration of more effective therapeutic targets.