The Effect of Androsterone as the Metabolite of Testosterone to Seizure Suppression
Journal of the Korean Neurological Association
;
: 142-146, 2009.
Artigo
em Coreano
| WPRIM
| ID: wpr-103701
ABSTRACT
BACKGROUND:
Androsterone is one of the major metabolites from testosterone whose clinical importance remains unclear. This study evaluated the effects of androsterone on seizure susceptibility in mouse models of epilepsy.METHODS:
The efficacy of androsterone (10~200 mg/kg, i.p.) against seizures induced by various GABA receptor antagonists and glutamate receptor agonists was evaluated.RESULTS:
Androsterone protected mice against seizures induced by PTZ (pentylenetetrazol), PCX (picrotoxin), and DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) in a dose-dependent manner. Androsterone did not protect against seizures induced by kainic acid, NMDA (N-methyl-D-aspartic acid), or 4-AP (4-aminopyridine) in mice.CONCLUSIONS:
These results suggest that androsterone exhibits anticonvulsant activity that occurs largely via nongenomic mechanisms. Testosterone-derived androsterone might be an endogenous protective neuroactive steroid in the brain.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Convulsões
/
Testosterona
/
Carbolinas
/
N-Metilaspartato
/
Receptores de Glutamato
/
Antagonistas GABAérgicos
/
Epilepsia
/
Ácido gama-Aminobutírico
/
Androsterona
/
Ácido Caínico
Limite:
Animais
Idioma:
Coreano
Revista:
Journal of the Korean Neurological Association
Ano de publicação:
2009
Tipo de documento:
Artigo
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