Your browser doesn't support javascript.
loading
The Effect of Cochinchina momordica Seed Extract on Gastric Acid Secretion and Morphologic Change in Aged Rat Stomach
Gut and Liver ; : 560-568, 2013.
Artigo em Inglês | WPRIM | ID: wpr-103740
ABSTRACT
BACKGROUND/

AIMS:

Cochinchina momordica seed extract (SK-MS10) has a gastric protective effect. We aimed to assess the effect of SK-MS10 on gastric acid secretion with morphologic changes in the aged rat.

METHODS:

Acid secretions were evaluated in the male F344 rats of four different ages (6-, 31-, 74-week, and 2-year). The 31-week-old rats were divided to three groups and continuously administered chow containing vehicle, SK-MS10 and lansoprazole, respectively. At the age of 74 weeks and 2 years, basal and stimulated acid was measured and the expression of mRNA and protein of H(+)-K(+)-ATPase were determined. The area of connective tissue of lamina propria was measured.

RESULTS:

Basal and stimulated gastric acid significantly decreased and connective tissue of lamina propria increased with age. The expression of mRNA and protein of H(+)-K(+)-ATPase significantly decreased with age. However, 74-week-old rats in the SK-MS10 group had higher stimulated gastric acid secretion than those in the vehicle and lansoprazole groups. In 2-year-old rats of SK-MS10 group, there was no increase of connective tissue.

CONCLUSIONS:

As SK-MS10 kept the capacity of acid secretion as well as connective tissue area to comparable to young rats, it might valuable to perform further research regarding mechanism of SK-MS10 as an antiaging agent in the stomach.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ratos Endogâmicos F344 / Sementes / Estômago / Envelhecimento / RNA Mensageiro / Pré-Escolar / Tecido Conjuntivo / Momordica / 2-Piridinilmetilsulfinilbenzimidazóis / Ácido Gástrico Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Gut and Liver Ano de publicação: 2013 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ratos Endogâmicos F344 / Sementes / Estômago / Envelhecimento / RNA Mensageiro / Pré-Escolar / Tecido Conjuntivo / Momordica / 2-Piridinilmetilsulfinilbenzimidazóis / Ácido Gástrico Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Gut and Liver Ano de publicação: 2013 Tipo de documento: Artigo