Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms
Gut and Liver
;
: 519-523, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-103746
ABSTRACT
BACKGROUND/AIMS:
Plasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas.METHODS:
We reviewed the medical records of 3,136 subjects who underwent colonoscopy as a screening exam. The subjects were classified into a case group with adenomas (n=990) and a control group (n=2,146). Plasma PAI-1 levels were categorized into three groups based on tertile.RESULTS:
The plasma levels of PAI-1 were significantly higher in adenoma cases than in controls (p=0.023). The prevalence of colorectal adenomas increased significantly with increasing levels of PAI-1 (p=0.038). In the adenoma group, advanced pathologic features, size, and number of adenomas did not differ among the three groups based on tertiles for plasma PAI-1 levels. Using multivariate analysis, we found that plasma level of PAI-1 was not associated with the risk of colorectal adenomas (p=0.675). Adjusted odds ratios for colorectal adenomas according to increasing plasma levels of PAI-1 were 0.980 (95% confidence interval [CI], 0.768 to 1.251) for the second-highest plasma level and 1.091 (95% CI, 0.898 to 1.326) for the highest level, compared with the lowest levels.CONCLUSIONS:
These results suggest that elevated plasma PAI-1 levels are not associated with the risk of colorectal neoplasms.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Plasminogênio
/
Ativadores de Plasminogênio
/
Neoplasias Colorretais
/
Adenoma
/
Razão de Chances
/
Programas de Rastreamento
/
Prontuários Médicos
/
Prevalência
/
Análise Multivariada
Tipo de estudo:
Estudo de etiologia
/
Estudo de prevalência
/
Estudo prognóstico
/
Estudo de rastreamento
Idioma:
Inglês
Revista:
Gut and Liver
Ano de publicação:
2013
Tipo de documento:
Artigo
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