Expressions of Smad gene and protein in skin pathological scar / 中国现代医生

ABSTRACT

Objective To observe expressions of Smad gene and protein in skin pathological scar. Methods Every ex-perimental samples were obtained from 136 patients,who underwent scar resection or were recruited healthy people,from April 2010 to April 2014,including 47 patients with keloid,44 patients with hypertrophic scar,45 healthy people. Each sample was taken by RT-PCR and flow cytometry and results were analyzed. Results The expressions of Smad3 and TGF-β1 gene showd that keloid group and hypertrophic scar group were more than normal skin group,the differ-ences were significant(P<0.05). Conclusion The expressions of Smad3 and TGF-β1 are important characters of hyper-trophic scar and keloid.