A Case of Light Chain Deposition Disease in a Patient with Diabetes and Nodular Glomerulosclerosis / 대한내과학회지
Korean Journal of Medicine
;
: 318-323, 2015.
Artigo
em Coreano
| WPRIM
| ID: wpr-103787
ABSTRACT
A 50 year-old male with a 10-year history of diabetes was admitted to the hospital for edema and foamy urine. At the time of admission, serum creatinine was 1.99 mg/dL and 24 h urine protein levels were 4.0 g/day. Renal biopsy showed nodular glomerulosclerosis. Immunofluorescence demonstrated the presence of kappa light chains along the glomerular and tubular basement membrane. Electron microscopy showed granular electron-dense deposits along the glomerular subendothelium and tubular basement membrane. Serum protein electrophoresis was negative for a monoclonal spike; however, urine protein electrophoresis demonstrated a monoclonal spike. Bone marrow examination was compatible with multiple myeloma and the patient was diagnosed with light-chain deposition disease associated with multiple myeloma. This report stresses the significant challenges that occur when diagnosing light-chain deposition disease in kidneys of patients with long standing diabetes, and discusses previously reported cases of light-chain deposition disease in Korea.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Membrana Basal
/
Biópsia
/
Exame de Medula Óssea
/
Microscopia Eletrônica
/
Imunofluorescência
/
Cadeias Leves de Imunoglobulina
/
Creatinina
/
Nefropatias Diabéticas
/
Edema
/
Eletroforese
Limite:
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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