Interferon-Alpha Induced Severe Hypothyroidism Followed by Graves' Disease in a Patient Infected with Hepatitis C Virus
International Journal of Thyroidology
; : 230-234, 2015.
Article
em En
| WPRIM
| ID: wpr-103829
Biblioteca responsável:
WPRO
ABSTRACT
Interferon-alpha (IFN-alpha) is an important therapeutic agent for hepatitis C virus (HCV) infection, but has various side effects including thyroiditis. We report a case of interferon-induced non-autoimmune hypothyroidism followed by autoimmune-medicated Graves' disease. A 59-year-old woman was diagnosed with chronic active hepatitis C; she had been treated with IFN-alpha and ribavirin for 24 weeks. Before starting the IFN-alpha, her thyroid function was normal and she was negative for autoantibodies. Severe hypothyroidism developed 5 weeks after halting the IFN-alpha, with the Graves' disease phase arising at 32 weeks. For accurate diagnosis and appropriate treatment of thyroid dysfunction during treatment with IFN-alpha, we need to understand and consider rare cases of multiphasic disorder involving both non-autoimmune and autoimmune thyroiditis induced by IFN-alpha.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Ribavirina
/
Autoanticorpos
/
Glândula Tireoide
/
Tireoidite
/
Tireoidite Autoimune
/
Doença de Graves
/
Interferons
/
Interferon-alfa
/
Hepatite C
/
Hepacivirus
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
International Journal of Thyroidology
Ano de publicação:
2015
Tipo de documento:
Article