Correlation between serum galectin-3,MMP-9 expression and neurological deficit after intravenous thrombolysis in patients with acute ischemic stroke / 中风与神经疾病杂志

ABSTRACT

@#Objective　To investigate the relationship between the expression of serum galectin-3 and matrix metalloproteinase-9 (MMP-9) and neurological deficit after intravenous thrombolysis in patients with acute ischemic stroke (AIS).Methods　The clinical data of 100 patients with AIS who received intravenous thrombolytic therapy in the hospital were retrospectively analyzed.The neurological deficit （NIHSS） of all patients after thrombolytic therapy was evaluated.They were divided into severe group (NIHSS score≥15，71 patients) and mild to moderate group (NIHSS score 0~14，29 patients),and the relationship between the levels of serum galectin-3 and MMP-9 and the neurological deficit after intravenous thrombolytic therapy of AIS patients was analyzed.Results　The serum galectin-3 and MMP-9 levels of severe group high than mild to moderate group (P<0.05).The high expression of serum galectin-3 and MMP-9 before thrombolysis may be the risk factors of severe neurological deficit after thrombolysis in AIS patients （OR=1.385、1.166，P<0.001、=0.002，95%CI1.160~1.653、1.060~1.282）.Besides,they can predict the risk of severe neurological deficit in patients with AIS after thrombolytic therapy (AUC=0.781、0.718).Conclusion　The levels of serum galectin-3 and MMP-9 in patients with AIS before thrombolysis are related to the neurological deficit after thrombolysis.Their overexpression may increase the risk of severe neurological deficit.