Association between Korean Schizophrenics and HLA-DRB1 Alleles / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 889-897, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-103928
ABSTRACT
OBJECTIVE:
A genetic predisposition is widely accepted in schizophrenia. This study was intended to find any association of HLA-DRB1 alleles with Korean schizophrenics and thereby compare the results of other ethnic groups.METHODS:
The subjects were 70 unrelated Korean patients. Low and high resolution typing of HLA-DRB1 alleles were performed. The comparison groups were 2,000 unrelated healthy Koreans for low resolution HLA-DR and 229 unrelated healthy Koreans for HLA-DRB1 alleles.RESULTS:
Gene frequencies of HLA-DR11(patients 9.0%, healthy control 3.8%, p=0.005) and HLA-DRB1*1101(patients 9.0%, healthy control 1.8%, p< .001) were significantly higher in Korean schizophrenics.CONCLUSIONS:
The frequency of HLA-DR11 (HLA-DRB1*1101) is significantly higher in Korean schizophrenics than in healthy Koreans. HLA-DR4 and HLA-DR1, which were known to be associated with Caucasian and Japanese schizophrenics, respectively, did not show statistical association with Korean schizophrenics. This association need to be reassured through further studies with families or association study with larger numbers of subjects.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Esquizofrenia
/
Etnicidade
/
Antígenos HLA-DR
/
Antígeno HLA-DR1
/
Antígeno HLA-DR4
/
Predisposição Genética para Doença
/
Povo Asiático
/
Alelos
/
Cadeias HLA-DRB1
/
Frequência do Gene
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Neuropsychiatric Association
Ano de publicação:
2000
Tipo de documento:
Artigo
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