Expression of Galectin⁃3 in peritoneal dialysate and its clinical significance / 安徽医科大学学报

ABSTRACT

Objective @#To observe the expression of Galectin⁃3 in peritoneal dialysis ( PD) fluid in patients with different dialysis ages , and to conduct correlation analysis with vascular endothelial growth factor ( VEGF) , fibronectin (FN) and related clinical indicators . @*Methods @#A total of 109 PD patients who were regularly followed up in the department of nephrology were divided into four groups according to different peritoneal dialysis ages . The concentrations of Galectin⁃3 , VEGF and FN were determined by enzyme⁃linked immunosorbent assay . The expression of Galectin⁃3 in peritoneal dialysate of the 4 groups was compared , the correlation with VEGF , FN and clinical related indexes was analyzed , and the correlation was analyzed by Spearman test . @*Results @# The concentration of VEGF in peritoneal dialysis patients in group D significantly increased ( P < 0. 05 ) . Galectin⁃3 expression levels were positively correlated with VEGF ( r = 0. 358 , P = 0. 022) , but not significantly correlated with FN ( r = 0. 121 , P = 0. 452) . Galectin⁃3 was positively correlated with clinical indicators parathyroid hormone (PTH) ( r = 0. 201 , P = 0. 037) , C ⁃reactive protein (CRP) ( r = 0. 357 , P < 0. 001) , left ventricular posterior wall dimensions ( LVPWD) ( r = 0. 213 , P = 0. 026) , and negatively correlated with clinical indicators total cholesterol (TC) ( r = - 0. 316 , P = 0. 001) . @*Conclusion @#The concentration of Galectin⁃3 in the dialysate of long⁃term peritoneal dialysis patients is significantly elevated , indicating that the expression of galectin⁃3 increases with the extension of peritoneal dialysis time , suggesting that the detection of galectin⁃3 levels may be helpful for the evaluation of early peritoneal fibrosis . The positive correlation with VEGF may suggest its role in promoting peritoneal angiogenesis and fibrosis . Moreover , it is positively correlated with clinical indicators PTH , CRP and LVPWD , suggesting that it has certain clinical guiding significance on microinflammatory state and myocardial remodeling .