The relationship between pulse pressure,pulse pressure index and early hematoma enlargement inspontaneous intracerebral hemorrhage / 中风与神经疾病杂志

ABSTRACT

@#Objective　To investigate the association between pulse pressure,pulse pressure index and early hematoma enlargement in spontaneous intracerebral hemorrhage (ICH).Methods　The pulse pressure and pulse pressure index of 428 patients with ICH was recorded.All patients were divided into growing hematoma group and stable hematoma group according to the existence of early hematoma enlargement and comparatively studied.Results　(1)One hundred and sixteen cases showed hematoma enlargement.The PP level was (84.81±17.36)mmHg in growing hematoma group and (67.06±16.86)mmHg in stable hematoma group.The PPI level was (0.45±0.07) in growing hematoma group and (0.39±0.68) in stable hematoma group.The PP and PPI levels of the growing hematoma group were significantly higher than those of the stable hematoma group (both P<0.05).(2)The prevalence of early hematoma enlargement increased along with the increase of PP and PPI (both P<0.05).(3)Receiver operating characteristic (ROC) curve analysis showed that the areas of PP and PPI under ROC curve was 0.779 （95%CI 0.730~0.827）and 0.726 （95%CI 0.671~0.780）.The best cutiff value for predicting the prevalence of hematoma enlargement of PP level was 70 mmHg.The sensitivity was 0.80 and the specificity was 0.72.The best cutiff value of PPI level was 0.43.The sensitivity was 0.64 and the specificity was 0.73.There was no significant difference between the area of PP and PPI under ROC curve (P>0.05).Conclusion　As risk factors of early hematoma enlargement,PP and PPI are associated with the prevalence of early hematoma enlargement in ICH.PP is the same as PPI in predicting the prevalence of hematoma enlargement.