Epidemiology and Characteristics of Metallo-beta-Lactamase-Producing Pseudomonas aeruginosa
Infection and Chemotherapy
;
: 81-97, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-104521
ABSTRACT
Metallo-beta-lactamase-producing Pseudomonas aeruginosa (MPPA) is an important nosocomial pathogen that shows resistance to all beta-lactam antibiotics except monobactams. There are various types of metallo-beta-lactamases (MBLs) in carbapenem-resistant P. aeruginosa including Imipenemase (IMP), Verona integron-encoded metallo-beta-lactamase (VIM), Sao Paulo metallo-beta-lactamase (SPM), Germany imipenemase (GIM), New Delhi metallo-beta-lactamase (NDM), Florence imipenemase (FIM). Each MBL gene is located on specific genetic elements including integrons, transposons, plasmids, or on the chromosome, in which they carry genes encoding determinants of resistance to carbapenems and other antibiotics, conferring multidrug resistance to P. aeruginosa. In addition, these genetic elements are transferable to other Gram-negative species, increasing the antimicrobial resistance rate and complicating the treatment of infected patients. Therefore, it is essential to understand the epidemiology, resistance mechanism, and molecular characteristics of MPPA for infection control and prevention of a possible global health crisis. Here, we highlight the characteristics of MPPA.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasmídeos
/
Pseudomonas aeruginosa
/
Monobactamas
/
Carbapenêmicos
/
Epidemiologia
/
Controle de Infecções
/
Resistência a Múltiplos Medicamentos
/
Integrons
/
Alemanha
/
Antibacterianos
Tipo de estudo:
Estudo de rastreamento
Limite:
Humanos
País/Região como assunto:
Europa
Idioma:
Inglês
Revista:
Infection and Chemotherapy
Ano de publicação:
2015
Tipo de documento:
Artigo
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