Molecular Genetic Study for FMR-1 Gene in Autistic Children / 신경정신의학
Journal of Korean Neuropsychiatric Association
; : 1479-1487, 1999.
Article
em Ko
| WPRIM
| ID: wpr-104565
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES: To elucidate an association of the fragile X syndrome with autism, Southern blot analysis was performed in 66 autistic children aged from 2 years to 11 years. METHODS: Subjects were 66 autistic children with of autistic disorder diagnosed by DSM-IV criteria and Childhood Autism Rating Scale-Korean version. Genomic DNA was extracted from peripheral blood and DNA was used to detect a FMR (Fragile Mental Retardation)-1 gene. Xho/PstI probes and two restriction enzymes (EcoRI, EagI)were used for Southern blot analysis. RESULTS: There were one boy with a methylated mosaic pattern and 3 boys and 2 girls with an unmethylated premutation band. But there was no full mutation pattern. CONCLUSION: Although the possibility of the relationship between autistic disorder and FMR-1 gene has been suggested, the results from this study do not provide any definite association of FMR-1 gene with autism in autistic children.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Transtorno Autístico
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DNA
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Southern Blotting
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Manual Diagnóstico e Estatístico de Transtornos Mentais
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Síndrome do Cromossomo X Frágil
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Biologia Molecular
Limite:
Child
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Female
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Humans
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Male
Idioma:
Ko
Revista:
Journal of Korean Neuropsychiatric Association
Ano de publicação:
1999
Tipo de documento:
Article