Molecular Genetic Study for FMR-1 Gene in Autistic Children / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 1479-1487, 1999.
Artigo
em Coreano
| WPRIM
| ID: wpr-104565
ABSTRACT
OBJECTIVES:
To elucidate an association of the fragile X syndrome with autism, Southern blot analysis was performed in 66 autistic children aged from 2 years to 11 years.METHODS:
Subjects were 66 autistic children with of autistic disorder diagnosed by DSM-IV criteria and Childhood Autism Rating Scale-Korean version. Genomic DNA was extracted from peripheral blood and DNA was used to detect a FMR (Fragile Mental Retardation)-1 gene. Xho/PstI probes and two restriction enzymes (EcoRI, EagI)were used for Southern blot analysis.RESULTS:
There were one boy with a methylated mosaic pattern and 3 boys and 2 girls with an unmethylated premutation band. But there was no full mutation pattern.CONCLUSION:
Although the possibility of the relationship between autistic disorder and FMR-1 gene has been suggested, the results from this study do not provide any definite association of FMR-1 gene with autism in autistic children.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transtorno Autístico
/
DNA
/
Southern Blotting
/
Manual Diagnóstico e Estatístico de Transtornos Mentais
/
Síndrome do Cromossomo X Frágil
/
Biologia Molecular
Limite:
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of Korean Neuropsychiatric Association
Ano de publicação:
1999
Tipo de documento:
Artigo
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